Effects of n-acetylcysteine administration as a preventive therapy for contrast-induced nephropathy after percutaneous coronary intervention in the elderly

Background: Contrast-induced nephropathy (CIN) is a common complication in patients undergoing percutaneous coronary intervention (PCI). The Elderly one of the risk factors for CIN and increase mortality. N-acetylcysteine recommended as preventive therapy post PCI due to its antioxidant activity. However, previous studies have shown that effectiveness n-acetylcysteine still inconsistent. Objective: aim this study was determine effect elderly. Method: This used retrospective design. Data collection carried out at General Hospital Jakarta from January until March 2020. medical records 2019 period were population. We included an elderly patient who underwent by purposive sampling technique obtained 78 samples. analyzed paired t-test Results: characteristic dominated males (66.67%) with GFR 20%). Overall, there average value (2.33±7.90) after administration (p=0.011).Conclusion: effective preventing incidence elderly.Keywords: N-acetylcysteine, therapy, contrast-induced (CIN), (PCI), IntisariLatar belakang: Contrast Induced Nephropathy diketahui sebagai komplikasi yang banyak terjadi pada pasien menjalani intervensi koroner perkutan (IKP). Usia lanjut merupakan salah satu faktor resiko terjadinya dan dapat meningkatkan mortalitas. N-asetilsistein direkomendasikan terapi pencegahan pasca IKP karena dihubungkan dengan aktivitas antioksidannya. Namun dari berbagai penelitian terkait efektivitas untuk mencegah masih beragam tidak konsisten.Tujuan: Tujuan ini mengetahui efek paska lansia.Metode: Penelitian menggunakan rancangan studi retrospektif. Pengambilan data dilakukan di rumah sakit umum bulan Januari – Maret Sampel digunakan adalah rekam medik periode tahun berusia lanjut. sampel teknik sampling, diperoleh memenuhi kriteria inklusi eksklusi. diolah dianalisis uji-t berpasangan N-asestilsistein lansia.Hasil: Karakteristik lansia didominasi oleh laki-laki (66,67%) nilai LFG 20%. Secara keseluruhan, peningkatan rata-rata setelah pemberian sebesar 2,33±7,90 (p=0,011).Kesimpulan: efektif dalam kejadian lansia.Kata kunci: N-asetilsistein, contrast induced (IKP),